The compact ampoule filling sealing machines are specially-designed machines for simultaneous filling and sealing operations to maximize efficiency. It is a machine designed to work in a sterile workplace, and is known for its simplicity, operational reliability and minimal maintenance factors. Automatic ampoule filling and sealing machine adopts the rectangular way to transfer ampoules, in such case, the transferring is steady, lower braking rate. A new type of clutch is mounted under the ampoule feeding hopper; therefore the ampoule can be stopped at any time while the machines are still running. So the ampoule consumption can be reduced. Electromagnetic switch is replaced with mechanical way in the part of filling stop system. It is more reliable and durable.